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Lehrstuhl für Bioverfahrenstechnik
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Stand November 2015
 
Prof. Dr.-Ing. Heike Dörnenburg
 

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    2010
     
  • Dörnenburg, H.:
    Cyclotide synthesis and supply: From plant to bioprocess.
    Biopolym. Pept. Sci. 93(9): online (2010).
     
  • Dörnenburg, H.:
    Chapter 26: Optimisation steps towards bioprocess development for the production of cyclotides. In: Applications of Plant Biotechnology: In vitro Propagation, Plant Transformations and Secondary Metabolite Production.
    Kumar, A. und Sopory, S. (Hrsg.)
    IK International Books, 542-562 (2010)
     
  • Dörnenburg, H.; Craik, D.J.:
    Cyclotides. In: Encyclopedia of Industrial Biotechnology. Bioprocess, Bioseparation, and Cell Technology.
    Flickinger, M.C. (Hrsg.), John Wiley & Sons. (2010)
     
  • Kiefer, J., Noack, K., Bartelmess, J., Walter, C., Dörnenburg, H. und Leipertz, A.:
    Vibrational structure of the polyunsaturated fatty acids eicosapentaenoic acid and arachidonic acid studied by infrared spectroscopy.
    J. Molec. Structure 965 (2010): 121-124.
     
  • 2009
     
  • Dörnenburg, H.:
    Progress in kalata peptide production via plant cell bioprocessing.
    Biotechnol. J. 4(6) (2009): 632-645.
     
  • Kaspari, K., Lürbke, V., Seydel, P. und Dörnenburg, H.
    Bioprozesstechnik: Mauerblümchen mit Potenzial - Pflanzenzellkulturen als Produktionsstätte von Sekundärmetaboliten.
    Bioforum 32 (4) (2009), 12-13.
     
  • Lürbke, V.H., Kaspari, K., Henkel, S., Scholze, A. und Dörnenburg, H.:
    Pflanzliche Zellsuspensionkulturen in Airlift- und Rührreaktoren.
    CIT 81(8) (2009), 1288.
     
  • Lürbke, V.H., Engelhardt, K., Heimstädt, T., Buchholz, R. und Dörnenburg, H.:
    Einfluss von Elicitoren auf die Cyclotid-Produktion in Pflanzenzellkulturen.
    CIT 81(8) (2009), 1289.
     
  • Lürbke, V.H., Engelhardt, K., Heimstädt, T., Buchholz, R. und Dörnenburg, H.:
    Effects of elicitors on cyclotide production in plant cell cultures.
    Chemie Ingenieur Technik 81(8) (2009), 1289.
     
  • Seydel, P., Walter, C. und Dörnenburg, H.:
    Scale-up of Oldenlandia affinis suspension cultures in photobioreactors for cyclotide production.
    Eng. Life Sci. J. 9 (3) (2009), 219-226.
     
  • 2008
     
  • Dörnenburg, H.:
    Plant cell technology - harnessing a biological approach for competitive cyclotides production.
    Biotechnol. Lett. 30 (8) (2008), 1311-1321.
     
  • Dörnenburg, H.:
    Production of cyclotides by plant suspension cultures.
    Agric. Rep. 50 (4) (2008), 29-30.
     
  • Dörnenburg, H.; Frickinger, P.; Seydel, P.:
    Plant cell-based processes for cyclotides production.
    Journal of Biotechnology 135 (1) (2008), 123-126.
     
  • Dörnenburg, H.; Seydel, P.:
    Effect of irradiation intensity on cell growth and kalata B1 accumulation in Oldenlandia affinis culture.
    Plant Cell Tiss. Organ Cult. 92 (1) (2008), 93-99.
     
  • Lürbke, V. und Dörnenburg, H.:
    Effects of spectral quality and medium components on Oldenlandia affinis suspension cultures.
    ESBES 7: 7th European Symposium on Biochemical Engineering, Faro, Portugal, September 7-10, 2008.
     
  • 2007
     
  • Seydel, P.; Gruber, C.W.; Craik, D.J., Dörnenburg, H.:
    Formation of cyclotides and variations in cyclotide expression in Oldenlandia affinis suspension culture
    Appl. Microbiol. Biotechnol. 77 (2) (2007), 275-284.
     
  • Dörnenburg, H.:
    Trends in plant cell biotechnology and its applications in cosmetic and pharmaceutical industry.
    Proceed. KEU ICC Seminar, Jeju, Korea (2007).
     
  • 2006
     
  • Popovska, N.; Ghanem, H.; Dörnenburg, H.:
    CDC-Silicon carbide composites as supports for immobilized enzymes.
    The International Carbon Conference, Carbon 2006, Aberdeen, Scotland, 16.-21. Juli 2006
     
  • Seydel, P.; Dörnenburg, H.:
    Cyclotide aus Oldenlandia affinis-Kulturen für die Wirkstoffentwicklung.
    CIT 79 (9) (2006), 1398-1399.
     
  • Seydel, P.; Frickinger, P.; Dörnenburg, H.:
    Production of bioactive cyclic peptides in plant cell cultures.
    The International Association for Plant Tissue Culture and Biotechnology, Bejing, China, 13.-18. August 2006.
     
  • Rechter, S.; König, T.; Auerochs, S.; Thulke, S.; Walter, H.; Dörnenburg, H.; Walter, C.; Marschall, M.:
    Antiviral activity of Arthrospira-derived spirulan-like substances.
    Antiviral Research 72 (3) (2006), 197-206.
     
  • Rechter, S.; König, T.; Auerochs, S.; Thulke, S.; Dörnenburg, H.; Walter, C.; Marschall, M.:
    Spirulan-like polysaccharides derived from microalgae Arthrospira possess a broad spectrum of antiviral activity.
    Jahrestreffen der Gesellschaft für Virologie, München 15.03.-18.03.2006.
     
  • Seydel, P.; Dörnenburg, H.:
    Establishment of in vitro plants, cell and tissue cultures from Oldenlandia affinis for the production of cyclic peptides.
    Plant Cell Tiss. Organ Cult. 85(3)(2006), 247-255.
     
  • 2005
     
  • Dörnenburg, H.; Seydel, P.; Buchholz, R.:
    Method for producing cyclic peptides from in vitro plant cell cultures.
    PCT Int. Appl., 46 pp. (2005).
     
  • Dörnenburg, H.; Seydel, P.; Buchholz, R.:
    Method for producing cyclic peptides from in vitro plant cell cultures.
    WO 2005/108596 (2005).
     
  • 2004
     
  • Dörnenburg, H.; Seydel, P.; Buchholz, R.:
    Verfahren zur Herstellung von In vitro-Pflanzenkulturen und deren Verwendung zur Gewinnung bioaktiver zyklischer Peptide pflanzlichen Ursprungs.
    DE 102004022585.0 (2004).
     
  • Dörnenburg, H.:
    Evaluation of immobilisation effects on metabolic activities and productivity in plant cell processes.
    Proc. Biochem. 39 (11) (2004), 1369-1375.
     
  • Seydel, P.; Wong, J.; Dörnenburg, H.:
    Gewinnung von Viola tricolor-Zellkulturen zur Produktion zyklischer Peptide.
    Dechema Workshop, Phytoextrakte - Produkte und Prozesse, Frankfurt (2004), P3, 35-37.
     
  • 2003
     
  • Dörnenburg, H.:
    Cell cultures: Strategies for plant metabolite production.
    Proceed. 9th German-Hungarian Seminar on Process Engineering, Berlin (2003).
     
  • 2002
     
  • Dörnenburg, H.; Buchholz, R.:
    Doppelt diplomiert und sprachgewandt.
    TU intern 8 (4) (2002), 4
     
  • 2001
     
  • Dörnenburg, H.:
    Process-induced stress reactions: A tool to increase bioactive compounds in plants, Proceed.
    8th German-Hungarian Seminar on Process Engineering, Miskolc, Ungarn, 2001.
     
  • Dörnenburg, H.:
    Strategies for the improvement of secondary metabolite production in plants, Proceed.
    The 2nd Korea - Germany Joint Biotechnology Symposium Biotechnology Today, Pusan, Korea, 2001.
     
  • Lang, C.; Dörnenburg, H.:
    Production of polygalacturonides and their use as food additives.
    WO 01/76609; PCT/EP 01/03998, 2001.
     
  • 2000
     
  • Davies, C.; Hunter, K.J.; Dörnenburg, H.:
    Method of increasing the water soluble antioxidant content in mechanically harvested peas.
    WO 00/43529; EP/PTC 00/00331, 2000.
     
  • Dörnenburg, H.:
    Biotechnologie auf dem Vormarsch: Auch bei Nahrung, Medizin und Umwelt kommt die Molekularbiologie zum Einsatz.
    TU intern 6 (10) (2000), 10.
     
  • Dörnenburg, H.; Buchholz, R.:
    Bioactive metabolites from micro and macro algae.
    Proceed. Internat. Seminar on Bioindustry, East Coastal Marine Bioresources Research Center, Kangnung, Korea, 2000.
     
  • Dörnenburg, H.; Lang, C.:
    Herstellung von Polygalakturoniden und ihre Verwendung als Lebensmittelzusatzstoffe.
    DE Patent 10019076, 2000.
     
  • Lang, C.; Dörnenburg, H.:
    Perspectives in the biological function and the technological application of polygalacturonases.
    Appl. Microbiol. Biotechnol. 53 (4) (2000), 366-375.
     
  • 1999
     
  • Dörnenburg, H.; Davies, C.:
    The relationship between lipid oxidation and antioxidant content in postharvest vegetables.
    Food Rev. Int. 15 (4) (1999), 435-453.
     
  • Dörnenburg, H.; Hemmerich, I.; Martens, G.; Wiesner, P.; Knorr, D.:
    Stress response and enzymatic browning reactions in potato cultures after high pressure treatment.
    In: Process Optimisation and Minimal Processing of Foods, Process Optimisation. 2nd Meeting.
    Vol. 4: High Pressure, Oliviera, J.C. and Knorr, D. (Eds.), Copernicus Programme Communications, P5.1. (1999).
     
  • Dörnenburg, H.; Schreck, S.; Knorr, D.:
    Evaluation of hydrogen peroxide production in tomato cultures as a stress reaction to high pressure treatment.
    In: Process Optimisation and Minimal Processing of Foods, Process Optimisation. 2nd Meeting.
    Vol. 4: High Pressure, Oliviera, J.C. and Knorr, D. (Eds.), Copernicus Programme, Communications, P5.2. (1999).
     
  • Dörnenburg, H.; Fenselau, K.; Wiesner, P.; Knorr, D.:
    Effect of high pressure treatment on the activity of pectinases, polyphenol oxidase, and peroxide of a plant cell culture from Lycopersicon esculentum.
    In: Process Optimisation and Minimal Processing of Foods, Process Optimisation. 2nd Meeting.
    Vol. 4: High Pressure, Oliviera, J.C. and Knorr, D. (Eds.), Copernicus Programme, Communications, P5.4. (1999)
     
  • 1998
     
  • Dörnenburg, H.:
    Peas Biochemical Markers: Antioxidants and lipoxygenase activity in cell free extracts of standard and lox2- peas.
    Science & Technology Report CW 98 0364. Unilever Research Colworth, Colworth House, Sharnbrook, Bedford, 1998.
     
  • Dörnenburg, H.; Davies, C.:
    Peas Biochemical Markers: Lipid oxidation and stress-related responses in standard peas and peas lacking lipoxygenase-2 isoenzyme.
    Science & Technology Report CW 98 0365. Unilever Research Colworth, Colworth House, Sharnbrook, Bedford, 1998.
     
  • Dörnenburg, H.; Knorr, D.:
    Monitoring the impact of high pressure processing on the biosynthesis of plant metabolites using plant cell cultures.
    Trends Food Sci. Technol. 9 (10) (1998), 355-361.
     
  • 1997
     
  • Dörnenburg, H.; Knorr, D.:
    Challenges and opportunities for metabolite production from plant cell and tissue cultures.
    Food Technol. 51 (11) (1997), 47-54.
     
  • Dörnenburg, H.; Knorr, D.:
    Evaluation of elicitor and high pressure induced enzymatic browning utilizing potato (Solanum tuberosum) suspension cultures as model system for plant tissues.
    J. Agric. Food Chem. 45 (10) (1997), 4173-4177.
     
  • Mönch, S.; Dörnenburg, H.; Knorr, D.:
    Drei-Phasen-Systeme zur kontinuierlichen Produktion von Anthrachinonen mit pflanzlichen Zellkulturen. Einfluß von Detergentien.
    BIOforum 20 (6) (1997), 290-294.
     
  • 1996
     
  • Dörnenburg, H.; Knorr, D.:
    Aktivitäten 1994/1995
    Fachgebiet Lebensmitteltechnologie I der TU Berlin.
    Lebensmitteltechnik 28 (5) (1996), 44-48.
     
  • Dörnenburg, H.; Knorr, D.:
    Development of highly stable multifunctional pectin/ chitosan coacervate capsules for cultured plant cells.
    Proceed. Intern. Workshop Bioencapsulation V, From Fundamentals to Industrial Applications, Potsdam 1996, P31, 1-6.
     
  • Dörnenburg, H.; Knorr, D.:
    Einsatz von Chitosan bei der Kultivierung pflanzlicher Zellkulturen - Ausbeutesteigerung, Permeabilisierung und Immobilisierung.
    BIOforum 19 (3) (1996), 52-62.
     
  • Dörnenburg, H.; Knorr, D.:
    Generation of colors and flavors in plant cell and tissue cultures.
    Crit. Rev. Plant Sci. 15 (2) (1996), 141-168.
     
  • Dörnenburg, H.; Knorr, D.:
    Production of phenolic flavor compounds with cultured cells and tissues of Vanilla species.
    Food Biotechnol. 10( 1) (1996), 75-92.
     
  • Dörnenburg, H.; Knorr, D.:
    Semicontinuous processes for anthraquinone production with immobilized Cruciata glabra cell cultures in a three-phase system.
    J. Biotechnol. 50 (1) (1996), 55-62.
     
  • Dörnenburg, H.; Schreck, S.; Knorr, D.:
    Evaluation of hydrogen peroxide production in tomato cultures as a stress reaction to high pressure treatment.
    Conference GDL/EFFoST, Minimal Processing of Foods - A Challenge for Quality and Safety, Köln, 6.-9. November 1996.
     
  • Dörnenburg, H.; Brumm, H.; Halfmann, K.; Knorr, D.:
    Effect of phenolic precursors on key enzymes and vallinin biosynthesis in vanilla (Vanilla planifolia) cell cultures.
    Institute of Food Technologists, 56th Annual Meeting, New Orleans, LA, 22.-26. Juni 1996.
     
  • Dörnenburg, H.; Fenselau, K.; Wiesner, P.; Knorr, D.:
    Effect of high pressure treatment on the activity of pectinases, polyphenol oxidase and peroxidase of a plant cell culture from Lycopersicon esculentum.
    Conference GDL/EFFoST, Minimal Processing of Foods - A Challenge for Quality and Safety, Köln, 6.-9. November 1996.
     
  • Dörnenburg, H.; Hiller, H.; Mönch, S.; Knorr, D.:
    Anthraquinones production with suspended and immobilized Gallum vernum cell cultures in three-phase systems.
    Institute of Food Technologists, 56th Annual Meeting, New Orleans, LA, 22.-26. Juni 1996.
     
  • Dörnenburg, H.; Hemmerich, I.; Martens, G.; Wiesner, P.; Knorr, D.:
    Stress responses and enzymatic browning reactions in potato cultures after high pressure treatment.
    Conference GDL/EFFoST, Minimal Processing of Foods - A Challenge for Quality and Safety, Köln, 6.-9. November 1996.
     
  • Hiller, H.; Dörnenburg, H.; Knorr, D.:
    Immobilisierung und Zwei-Phasen-Kultivierung pflanzlicher Zellkulturen - Biosynthese und Akkumulation von Anthrachinonen bei Galium vernum.
    BioTec 8 (2) (1996), 42-49.
     
  • Schreck, S.; Dörnenburg, H.; Knorr, D.:
    Evaluation of hydrogen peroxide production in tomato (Lycopersicon esculentum) suspension cultures as a stress reaction to high pressure treatment.
    Food Biotechnol. 10 (2) (1996), 163-171.
     
  • 1995
     
  • Dörnenburg, H.; Knorr, D.:
    Strategies for the improvement of secondary metabolite production in plant cell cultures.
    Enzyme Microb. Technol. 17 (8) (1995), 674-684.
     
  • Lux-Pfister, C.; Dörnenburg, H.; Knorr, D.:
    Bioreaktoren für pflanzliche Zellkulturen - Kultivierung von Galium vernum Suspensionskulturen im Hubstrahlbioreaktor.
    BioTec 7 (3) (1995), 28-32.
     
  • 1994
     
  • Dörnenburg, H.; Knorr, D.:
    Effectiveness of plant-derived and microbial polysaccharides as elicitors for anthraquinone synthesis in Morinda citrifolia cultures.
    J. Agric. Food Chem. 42 (1994), 1048-1052.
     
  • Dörnenburg, H.; Knorr, D.:
    Elicitation of chitinases and anthraquinones in Morinda citrifolia cell cultures.
    Food Biotechnol. 8 (1) (1994), 57-65.
     
  • Dörnenburg, H.; Lang-Hinrichs, C.:
    Genetic engineering in food biotechnology.
    Chem. Ind. 13 (1994), 506-510.
     
  • 1993
     
  • Dörnenburg, H.; Knorr, D.:
    Cellular permeabilization of cultured plant tissues by electric field pulses and high pressure for the recovery of secondary metabolites.
    Food Biotechnol. 7 (1) (1993), 35-48.
     
  • Knorr, D.; Caster, C.; Dörnenburg, H.; Dorn, R.; Gräf, S.; Havkin-Frenkel, D.; Podstolski, A.; Werrmann, U.:
    Biosynthesis and yield improvement of food ingredients from plant cell and tissue culture.
    Food Technol. 47 (12) (1993), 57-63.
     
  • 1992
     
  • Dörnenburg, H.; Knorr, D.:
    Release of intracellularly stored anthraquinones by enzymatic permeabilization of viable plant cells.
    Proc. Biochem. 27 (3) (1992), 161-166.
     
  • Knorr, D.; Böttcher, A.; Dörnenburg, H.; Eshtiaghi, M.; Oxen, P.; Richwin, A.; Seyderhelm, I.:
    High pressure effects on microorganisms, enzyme activity and food functionality.
    In: High Pressure and Biotechnology, Balny, C., Hayashi, K., Heremans, K. und Masson, P. (Hrsg.), Colloque INSERM/John Libbey Eurotext Ltd., Montrouge, France 1992, 211-217.
     
  • Knorr, D.; Caster, C.; Dörnenburg, H.; Dorn, R.; Havkin-Frenkel, D.; Podstolski, A.; Semrau, S.; Teichgräber, P.; Werrmann, U.; Zache, U.:
    Plant cells for the production of food ingredients.
    In: Harnessing Biotechnology for the 21st Century, Ladisch, M.R. und Bose, A. (Hrsg.), American Chemical Society, Washington, DC (1992), 519-523.
     
  • 1990
     
  • Paulmann, H.; Dörnenburg, H.; Knorr, D.:
    Chitosan as elicitor of chitinase in plant cell cultures.
    Food Biotechnology (New York) 4 (1990), 484.
     
  • Dörnenburg, H.; Werrmann, U.; Knorr, D.:
    Improvement of secondary metabolite production by precursor addition to cell cultures of Anethurm-Graveolens.
    Food Technol. (New York) 4 (1990), 477.
     
  • Knorr, D.; Beaumont, M.D.; Caster, C.S.; Dörnenburg, H.; Gross, B.; Pandya, Y.; Romagnoli, L.G.:
    Plant tissue culture for the production of naturally derived food ingredients.
    Food Technol. 44 (6) (1990), 71-79.
     
  • Knorr, D.; Pandya, Y.; Dörnenburg, H.:
    Immobilization of plant cell cultures in complex coacervate capsules for secondary metabolite production. In: Proceedings of the International Conference on Biotechnology and Food
    Hohenheim University, Stuttgart, February 20-24, 1989, Gierschner, K., Hammes, W.P. und Hartmeier, W. (Hrsg.), Marcel Decker, Inc., New York, Food Biotechnol. 4 (1) (1990), 409-420.
     

 
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