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Lehrstuhl für Bioverfahrenstechnik
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Stand November 2015
 
Prof. Dr. Rainer Buchholz
 

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    2015
     
  1. Werner, M.; Schmoldt, D.; Hilbrig, F.; Jerome, V.; Raup, A.; Zambrano, K.; Hübner, H.; Buchholz, R.; Freitag, R.:
    High cell density cultivation of human leukemia T cells (jurkat cells) in semipermeable polyelectrolyte microcapsules.
    Engineering in Life Sciences 15(4) (2015), 357-367.
     
  2. Taeger, C.D.; Friedrich, O.; Dragu, A.; Weigand, A.; Hobe, F.; Drechsler, C.; Geppert, C.I.; Arkudas, A.; Münch, F.; Buchholz, R.; Pollmann, C.; Schramm, A.; Birkholz, T.; Horch, R.E.; Präbst, K.:
    Assessing viability of extracorporeal preserved muscle transplants using external field stimulation: a novel tool to improve methods prolonging bridge-to-transplantation time.
    Scientific Reports 5 (2015).
     
  3. Heining, M.; Buchholz, R.:
    Photobioreactors with internal illumination - A survey and comparison.
    Biotechnology Journal 10(8) (2015), 1131-1137.
     
  4. Heilmann, M.; Jurkowski, W.; Buchholz, R.; Brück, T.; Becker, A.M.:
    Biosorption of Neodymium by Selected Photoautotrophic and Heterotrophic Species.
    Chemical Engineering & Process Technology 6(4) (2015).
     
  5. Glemser, M.; Schmidt, J.; Heining, M.; Becker, A.M.; Arnold, O.; Garbe, D.; Buchholz, R.; Brück, T.:
    Licht ins Grüne.
    Laborpraxis 5/2015 (2015), 24-26.
     
  6. Dakhil, H.; Wierschem, A.; Gilbert, D.F.; Amtmann, A.; Hübner, H.; Buchholz, R.; Friedrich, O.:
    Viscoelastic Measurements of Cells in a Rotational Rheometer.
    Chemie Ingenieur Technik 87(8) (2015), 1106.
     
  7. 2014
     
  8. Sutor, A.; Heining, M.; Lindenberger, C.; Buchholz, R.:
    Method for optimizing the field coils of internally illuminated photobioreactors.
    IEEE Transactions of Magnetics 50(11) (2014).
     
  9. Schöll, S.; Mualla, F.; Sommerfeldt, B.; Steidl, S.; Maier, A.; Buchholz, R.; Hornegger, J.:
    Influence of the phase effect on gradient-based and statistics-based focus measures in bright field microscopy.
    Journal of Microscopy 254(2) (2014), 65-74.
     
  10. Schmoldt, D.; Jerome, V.; Freitag, R.; Hübner, H.; Buchholz, R.:
    Proliferation humaner primärer T-Lymphozyten in Polyelektrolytkapseln.
    Chemie Ingenieur Technik 86(9) (2014), 1401-1426.
     
  11. Mualla, F.; Schöll, S.; Sommerfeldt, B.; Steidl, S.; Buchholz, R.; Hornegger, J.:
    Improving joint learning of suspended and adherent cell detection using low-pass monogenic phase and transport of intensity equation.
    Paper presented at the 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI (2014), 927-930.
     
  12. Mualla, F.; Schöll, S.; Sommerfeldt, B.; Maier, A.; Steidl, S.; Buchholz, R.; Hornegger, J.:
    Unsupervised unstained cell detection by SIFT keypoint clustering and self-labeling algorithm.
    Lecture notes in Computer Science 8675 LNCS, Part 3 (2014), 377-384.
     
  13. Mualla, F.; Schöll, S.; Sommerfeldt, B.; Maier, A.; Steidl, S.; Buchholz, R.; Hornegger, J.:
    Using the low-pass monogenic signal framework for cell/background classification on multiple cell lines in bright-field microscope images.
    International Journal of Computerassisted Radiology and Surgery 9(3) (2014), 379-386.
     
  14. Kaiser, P.; Werner, M.; Jerome, V.; Hübner, H.; Buchholz, R.; Freitag, R.:
    Cell retention by encapsulation for the cultivation of Jurkat cells ins fixed and fluidized bed reactors.
    Biotechnology and Bioengineering 111(12) (2014), 2571-2579.
     
  15. Heining, M.; Sutor, A.; Stute, S.C.; Lindenberger, C.P.; Buchholz, R.:
    Internal illumination of photobioreactors via wireless light emitters: a proof of concept.
    Journal of Applied Phycology 27(1) (2014), 59-66.
     
  16. Buchholz, R.; Heining, M.; Lindenberger, C.; Manstetten, P.:
    Reactor with electroluminescence particles in the reaction medium.
    Patent (2014).
     
  17. Ahmed, I.; Hübner, H.; Buchholz, R.:
    Establishment and Characterization of three New Embryonic Spodoptera littoralis Cell Lines and Testing their Susceptibility to SpliMNPV.
    In: Brueck, T. (ed.) Industrial Biotechnology - Made in Germany: The path from policies to sustainable energy, commodity and specialty products. JSM Biotechnology & Biomedical Engineering 2 (2014), 1031,2.
     
  18. 2013
     
  19. Werner, M.; Biss, K.; Jerome, V.; Hilbrig, F.; Freitag, R.; Zambrano, K.; Hübner, H.; Buchholz, R.; Mahou, R.; Wandrey, C.:
    Use of the mitochondria toxicity assay for quantifying the viable cell density of microencapsulated Jurkat cells.
    Biotechnology Progress 29 (2013), 986-993.
     
  20. Noack, K.; Eskofier, B.; Kiefer, J.; Dilk, C.; Bilow, G.; Schirmer, M.; Buchholz, R.; Leipertz, A.:
    Combined shifted-excitation Raman difference spectroscopy and support vector regression for monitoring the algal production of complex polysaccharides.
    The Analyst 138 (2013), 5639-5646.
     
  21. Klein, B.; Buchholz, R.:
    Microalgae as sources of nutraceuticals.
    In: McNeil, B.; Archer, D.; Giavasis, I.; Harvey, L (Eds.): Microbial production of food ingredients, enzymes and nutraceuticals. (2013), 559-570.
     
  22. Geier, S.; Buchholz, R.:
    Mikroalgen: Produktionsorganismus der Zukunft?
    BioSpektrum 19(3) (2013), 328-331.
     
  23. Buchholz, M.; Buchholz, R.:
    System for regulating temperature and humidity in enclosure.
    Patent (2013).
     
  24. 2012
     
  25. Noack, K.; Dilk, C.; Schirmer, M.; Klein, B.C.; Kiefer, J.; Buchholz, R.; Leipertz, A.:
    Raman difference spectroscopy approach for monitoring of a bioreactor.
    Conference on Lasers and Electro-Optics, CLEO (2012), art. no. 6325617.
     
  26. Lindenberger, C.; Pflug, L.; Hübner, H.; Buchholz, R.:
    A novel model for studying baculovirus infection process.
    Biotechnol. Bioprocess Engineering 17 (2012), 211-217.
     
  27. Klein, B.C.; Walter, C.; Lange, H.A.; Buchholz, R.:
    Microalgae as natural sources for antioxidative compounds.
    Journal of Applied Phycology 24(5) (2012), 1133-1139.
     
  28. Geier, S.C.; Huyer, S.; Präbst, K.; Husmann, M.; Walter, C.; Buchholz, R.:
    Outdoor cultivation of Chlamydomonas reinhardtii for photobiological hydrogen production.
    Journal of Applied Phycology 24 (2012), 319-327.
     
  29. Dragu, A.; Taeger, C.; Buchholz, R.; Sommerfeldt, B.; Hübner, H.; Birkholz, T.; Kleinmann, J.; Münch, F.; Horch, R.; Präbst, K.:
    Online oxygen measurements in ex vivo perfused muscle tissue in a porcine model using dynamic quenching methods.
    Arch Orthop Trauma Surg. 132(5) (2012), 655-661.
     
  30. Buchholz, R.; Budde, B.; Dörr, S.; Hitzbleck, J.; Köhler, K.; Meier, S.M.; Schönberger, J.; Storch, D.; von Sperber, F.; Walter, C.:
    Surface coating, useful for preventing fouling in aquatic environment, comprises one phototrophic microorganism in a formulation comprising polyurethane component.
    Patent (2012).
     
  31. 2011
     
  32. Naumann, I.; Klein, B.C.; Bartel, S.J.; Darsow, K.H.; Buchholz, R.; Lange, H.A.:
    Identification of sulfoquinovosyldiacyglycerides from Phaeodactylum tricornutum by matrix-assisted laser desorption/ ionization Q Trap time-of-flight hybrid mass spectrometry.
    Rapid Communications of Mass Spectrometry 25 (2011), 2517-2523.
     
  33. Klein, B.; Bartel, S.J.; Darsow, K.H.; Naumann, I.; Walter, C.; Buchholz, R.; Lange, H.A.:
    Identification of Coenzyme Q10 from Porphyridium pureourem by MALDI Curved Field Reflectron Mass Spectrometry.
    Journal of Phycology 47 (2011), 687-691.
     
  34. Bartel, S.; Doellinger, J.; Darsow, K.; Bourquain, D.; Buchholz, R.; Nitzsche, A.; Lange, H.A.:
    Proteome analysis of vaccinia virus IHD-W-infected HEK 293 cells with 2-dimensional gel electrophoresis and MALDI-PSD-TOF MS of an solid phase support N-terminally sulfonated peptides.
    Virology Journal 8 (2011), 380.
     
  35. 2010
     
  36. Skwarek, M.; Lade, T.; Werner, M.; Jerome, V.; Zambrano, K.; Meier, S.; Hübner, H.; Buchholz, R.; Freitag, R.:
    Expandierte Proliferation von Jurkat-T-Zellen unter Zuhilfenahme spezieller Zellkulturtechniken.
    Chemie Ingenieur Technik 81(1-2) (2010), 42.
     
  37. Al-Mhanna, N.M.M.; Hübner, H.; Buchholz, R.:
    Optimization of parameters growth conditions of yeast biomass during single cell protein production by using simplex method.
    Chemical Engineering Transactions 21 (2010), 475-480.
     
  38. 2009
     
  39. Lürbke, V.H.; Engelhardt, K.; Heimstädt, T.; Buchholz, R.; Dörnenburg, H.:
    Effect of elicitors on cyclotide production in plant cell cultures.
    Chemie Ingenieur Technik 81(8)(2009), 1289.
     
  40. Lichtenstein, N.; Quellmalz, K.; Bernards, M.; Buchholz, R.; Kraus, W.; Poppe, M.:
    The release of aromatic amines from legacy powder stains used from 1950 to 1970 for the staining of wood.
    Gefahrstoffe - Reinhaltung der Luft 69(6) (2009), 258-262.
     
  41. Engelhardt, K.; Heimstädt T.; Buchholz, R.; Dörnenburg, H.:
    Einfluss von Elicitoren auf die Cyclotid-Produktion in Pflanzenzellkulturen.
    Chemie Ingenieur Technik 81(8) (2009), 1289.
     
  42. Duerr, O.; Buchholz, R.; Lange, H.; Klein, B.; Walter, C.:
    Increasing coenzyme Q10 content of phototrophic microorganism, comprises induction of oxidative stress by co-incubating stress-induced substances and increasing surface irradiation intensity, and/or addition of oleate to the culture medium.
    Patent (2009).
     
  43. Buchholz, R.; Lange, H.; Klein, B.; Walter, C.; Duerr, B.:
    Method for increasing the coenzyme Q10 content of phototrophic microorganisms.
    PCT Int. Appl., 33 pp. (2009).
     
  44. Acevedo, C.; Weinstein-Oppenheimer, C.; Brown, D.I.; Hübner, H.; Buchholz, R.; Young, M.E.:
    A mathematical model for the design of fibrin microcapsules with skin cells.
    Bioprocess and Biosystems Engineering 32(3) (2009), 341-351.
     
  45. Acevedo, C.; Stach, M.H.; Amtmann, A.; Young, M.E.; Reyes, J.G.; Hübner, H.; Buchholz, R.:
    Measuring beta-Glactosidase activity at pH6 with a differential pH sensor.
    Electronic Journal of Biotechnology 12(2) (2009).
     
  46. 2008
     
  47. Klein, B.C.; Walter, C.; Lange, H.A.; Buchholz, R.:
    Microalgae - Natural sources for high-grade cosmetic products.
    Vortragspräsentation: 11th International Conference on Applied Phycology, Galway, Ireland, Juni (2008).
     
  48. Klein, B.C.; Walter, C.; Bartel, S.J.; Darsow, K.H.; Lange, H.A.; Buchholz, R.:
    Microalgae - Natural sources for high-grade cosmetic products.
    Vortragspräsentation: The World Congress on Industrial Biotechnology & Bioprocessing, Chicago, USA, April, 2008
     
  49. Klein, B.C.; Darsow, K.H.; Bartel, S.J.; Buchholz, R.; Lange, H.A.:
    LC/MS - Strukturgestütztes Screening
    Biotechnologische Gewinnung von Co-Enzym Q10
    Vortragspräsentation: LC-MS Tage, Heidelberg, Mai 2008.
     
  50. Bunke, G.; Götz, P.; Buchholz, R.:
    Metal Removal by Biomass: Physico-Chemical Elimination Methods.
    03/2008: 430-452; ISBN: 9783527620944 (2008).
     
  51. 2007
     
  52. Naumann, I.; Walter, C.; Thulke, S.; Darsow, K.H.; Siegert, W.; Lange, H.A.; Buchholz, R.:
    The Ocean as a Drug Source - Antiviral active sulfoquinovosyldiacylglycerides from phototrophic microorganisms.
    Posterpräsentation: Pacific Rim Summit on Industrial Biotechnology and Bioenergy, Honolulu, USA, November 2007.
     
  53. Klein, B.C.; Walter, C.; Bartel, S.J.; Darsow, K.H.; Lange, H.A.; Buchholz, R.:
    The Marine "Foundation of Youth" - MALDI CFRplus mass spectrometry - the evidence of co-enzyme Q10 in Porphyridium purpureum.
    Vortragspräsentation: Pacific Rim Summit on Industrial Biotechnology and Bioenergy, Honolulu, USA, November 2007.
     
  54. Thulke, S.; Naumann, I.; Buchholz, R.; Siegert, W.; Radonic, A.; Lange, H.; Walter, C.:
    SQDGs – potential antiviral agents.
    Posterpräsentation: Third European Congress of Virology, Nürnberg, Germany (2007).
     
  55. Klein, B.C.; Walter, C.; Bartel, S.J.; Lange, H.A.; Buchholz, R.:
    Porphyridium purpureum - A natural source for antioxidant co-enzyme Q10.
    Posterpräsentation: European BioPerspectives, Köln, Germany (2007).
     
  56. Walter, C.; König, T.; Naumann, I.; Buchholz, R.:
    Microalgae as Sources of Pharmaceuticals.
    Posterpräsentation: European BioPerspectives, Köln, Germany (2007).
     
  57. König, T.; Thulke, S.; Marschall, M.; Siegert, M.; Buchholz, R.; Walter, C.:
    Production of Antiviral Compounds of Phototrophic Microorganisms.
    7th European Workshop "Biotechnology of Microalgae". Nuthetal, Germany, June 2007.
     
  58. Darsow, K.H.; Lange, H.A.; Resch, M.; Walter, C.; Buchholz, R.:
    Analysis of a Chlorosulfolipid from Ochromonas danica by matrix-assisted laser desorption/ionisation quadrupole ion trap time-of-flight mass spectrometry.
    Rapid Commun. Mass Spectrom. 21 (2007), 2188-2194.
     
  59. Walter, C.; König, T.; Buchholz, R.; Thulke, S.; Marschall, M.; Paulsen, B.S.; Nitsche, A.; Rechter, S.:
    Pharmaceutical composition with an extracellular polyanion from Arthrospira
    PCT Int. Appl., 53 pp. (2007).
     
  60. Naumann, I.; Darsow, K.H.; Walter, C.; Lange, H.A.; Buchholz, R.:
    Identification of Sulfoglycolipids from the algae P. purpureum by matrix assisted laser desorption/ionisation quadrupole ion trap time-of-flight mass spectrometry.
    Rapid Commun. Mass Spectrom. 21 (2007), 3185 – 3192.
     
  61. 2006
     
  62. Wilke, A.; Buchholz, R.; Bunke, G.::
    Selective Biosorption of Heavy Metals by Algae
    Environmental Biotechnology 2 (2) (2006), 47-56.
     
  63. König, T.; Thulke, S.; Rechter, S.; Naumann, I.; Nitsche, A.; Marschall, M.; Siegert, W.; Buchholz, R.; Walter, C.:
    Screening und Biosynthese von Komponenten aus Mikroalgen mit Aktivitäten gegen humanpathogene Viren.
    DECHEMA-Jahrestagung, Wiesbaden, September 2006.
     
  64. Tan, A.W.I.; Fischbach, M.; Hübner, H.; Buchholz, R.; Hummel, W.; Daussmann, T.; Wandrey, C.; Liese, A.:
    Synthesis of enantiopure (5R)-hydroxyhexane-2-one with immobilised whole cells of Lactobacillus kefiri. Appl. Microbiol. Biotechnol. 71 (2006), 289-293.
     
  65. König, T.; Thulke, S.; Rechter, S.; Naumann, I.; Nitsche, A.; Marschall, M.; Siegert, W.; Buchholz, R.; Walter, C.:
    Screening and biosynthesis of microalgae compounds with activities towards human pathogen viruses.
    From Functional Genomics to Natural Products of Marine Microorganisms, Greifswald, Juni 2006.
     
  66. Son, J.H.; Buchholz, R.; Park, J.K.; Kim, S.K.:
    Production of baculoviruses and expression of green fluorescent protein in immobilised Sf21 insect cell cultivation
    Biochemical Engineering Journal 29 (2006) 1-2, 55-61.
     
  67. Thulke, S.; Radonic, A.; König, T.; Walter, C.; Buchholz, R.; Siegert, W.:
    Testing of microalgae extract which exhibits a high activity towards HCMV in vitro by inhibition of virus attachment.
    Jahrestreffen der Gesellschaft für Virologie, München 15.03.-18.03.2006.
     
  68. König, T.; Thulke, S.; Naumann, I.; Siegert, W.; Buchholz, R.; Walter, C.:
    Komponenten aus Mikroalgen mit Aktivitäten gegen humanpathogene Viren.
    Chemie Ingenieur Technik 9 (2006), 1382-1383.
     
  69. Buchholz, M.; Buchholz, R.; Jochum, P.; Zaragoza, G.; Perez-Parra, J.:
    Temperature and humidity control in the watergy greenhouse
    Acta Horticulturae 719 (2006), 401-407.
     
  70. Geppert, E.; Lange, H.A.; Falb, M.; Hübner, H.; Buchholz, R.:
    13-Hydroperoxid-Dependent Isomerase in Immortalized Hepatocytes.
    Journal of Chromatography B (submitted) (2006).
     
  71. 2005
     
  72. Meier, St. M.; Hübner, H.; Buchholz, R.:
    Single-cell bioreactors as end of miniaturization approaches in biotechnology: progresses with characterised bioreactors and a glance into the future
    Bioprocess and Biosystems Engineering; Springer Verlag GmbH; ISNN: 1615-7591 (Paper), 1615-7605 (Online), 2005.
     
  73. Kwak, J.K.; Koo, J.G.; Park, S.W.; Cho, M.G., Kang, B.C.; Buchholz, R.; Götz, P.:
    Optimal criterion for the scale-up production of schizophyllan in the stirred tank reactor.
    Journal of Microbiology and Biotechnology 15 (2005) 1, 1-6.
     
  74. Meier, St.M.; Hübner, H.; Buchholz, R.:
    Single-cell bioreactors as end of miniaturization approaches in biotechnology: progresses with characterised bioreactors and a glance into the future.
    Bioprocess and Biosystems Engineering 28(2)(2005), 95-107.
     
  75. Dörnenburg, H.; Seydel, P.; Buchholz, R.:
    Method for producing cyclic peptides from in vitro plant cell cultures.
    WO 2005/108596 (2005).
     
  76. Dörnenburg, H.; Seydel, P.; Buchholz, R.:
    Method for producing cyclic peptides from in vitro plant cell cultures.
    PCT Int. Appl., 46 pp. (2005).
     
  77. 2004
     
  78. Dörnenburg, H.; Seydel, P.; Buchholz, R.:
    Verfahren zur Herstellung von In vitro-Pflanzenkulturen und deren Verwendung zur Gewinnung bioaktiver zyklischer Peptide pflanzlichen Ursprungs.
    DE 102004022585.0 (2004).
     
  79. Son, J.H.; Buchholz, R.; Kim, S.K.:
    Mass production of HzSNPV baculoviruses in immobilized Heliothis zea (HzAM1) insect cell culture
    Journal of Microbiology and Biotechnology 14 (2004) 2, 395-400.
     
  80. Son, J.H.; Buchholz, R.; Kim, S.K.:
    An immobilized culture of Choristoneura fumiferana cells for high production of CfMNPV.
    Biotechnology and Bioprocess Engineering 9 (2004) 5, 352-355.
     
  81. König, T.; Buchholz, R.; Walter, C.:
    Scale-up einer monoseptischen Kultivierung von Porphyridium purpureum.
    Posterpräsentation: BioPerspectives Wiesbaden, Germany (2004).
     
  82. König, T.; Lammers, B.; Buchholz, R.; Walter, C.; Tuschy, M.; Brandt, A.:
    Aufarbeitung von hochmolekularen Polysacchariden aus einem Kulturüberstand von Porphyridium purpureum.
    Posterpräsentation: BioPerspectives Wiesbaden, Germany (2004).
     
  83. Stich, S.; Radonic, A.; König, T.; Walter, C.; Buchholz, R.; Siegert, W.; Thulke, S.:
    Etablierung eines Wirkstoffscreenings gegen das humane Cytomegalievirus.
    Posterpräsentation: BioPerspectives Wiesbaden, Germany (2004).
     
  84. Thulke, S.; Stich, S.; Radonic, A.; König, T.; Walter, C.; Buchholz, R; Siegert, W.:
    Etablierung eines Wirkstoff-Screenings gegen HCMV.
    Posterpräsentation: Gemeinsame Jahrestagung der Gesellschaften für Hämatologie und Onkologie von Deutschland, &Ouuml;sterreich und der Schweiz; Innsbruck, Austria (2004).
     
  85. 2003
     
  86. Kwak, J.-K.; Park, S. W.; Koo, J.-G.; Buchholz R.; Goetz, P.:
    Enhancement of the Non-Specific Defence Activities in Carp (Cyprinus carpio) and Flounder (Paralichthys olivcaces) by Oral Administration of Schiczophyllan.
    Acta Biotechnol. 23 (2003) 4, 359-371.
     
  87. Walter, C.; Buchholz, R.:
    Monoseptic cultivation of phototrophic microorganisms.
    Biomolecular Engineering 20, 2 (2003), 42-43.
     
  88. König, T.; Walter, C.; Thulke, S.; Lange, H.; Siegert, W.; Buchholz, R.:
    Optimized screening program of bioactive compounds of phototrophic microorganisms.
    Biomolecular Engineering 20, 4-6 (2003), 65.
     
  89. Walter, C.; Buchholz, R.:
    Microalgae - An Extensive Source of New Natural Substances for Medicine.
    Biotechnology in Bavaria (2003), 24-27.
     
  90. Walter, C.; Steinau, T.; Gerbsch, N.; Buchholz, R.:
    Monoseptic cultivation of phototrophic microorganisms - development and scale-up of a photobioreactor system with thermal sterilization.
    Biomolecular Engineering 20 (2003), 261-271.
     
  91. König, T.; Walter, C.; Thulke, S.; Lange, H.A.; Siegert, W.; Buchholz, R.:
    Optimized screeing program of bioactive compounds of phototrophic microorganisms.
    Posterpresentation: Symposium Marine Biotechnology: Basics and Applications. Matalascanas, Spain (2003).
     
  92. Walter, C.; Steinau, T.; Gerbsch, N.; Buchholz, R.:
    Monoseptic cultivation of phototrophic microorganisms - development and scale-up of a photobioreactor system with thermal sterilization.
    Biomolecular Engineering 20 (2003), 1-11
    http://www.elsevier.com/locate/geneanabioeng
    Vol. 20/4-6, 261-271.
     
  93. 2002
     
  94. Bohlmann, J.; Schneider, C.; Andresen, H.; Buchholz, R.:
    Optimierung des Herstellungsprozesses von Natrium-Cellulosesulfat (NaCS) zur Mikroverkapselung von Zellkulturen
    CIT 74 (2002), 359-363.
     
  95. Hübner, H.; Buchholz, R.:
    Immunreaktion des Körpers durch Membran verhindert.
    Medizin Report (2002) 3, 20-21.
     
  96. Walter, C.; Gerbsch, N.; Steinau, T.; Buchholz, R.:
    Photobioreactors and process developments for the controlled cultivation of phototrophic microorganisms under monoseptic conditions.
    Proceedings and oral presentation 1st Congress of the International Society of Applied Phycology, 9th International Conference on Applied Algology, Almeria, Spain (2002).
     
  97. Bohlmann, J.T.; Buchholz, R.:
    Development of a new ramiet-membrane reactor for cell culture technology by means of CFD.
    Chemie Ingenieur Technik 74(5) (2002), 662.
     
  98. Bohlmann, J.T.; Schneider, C.; Andresen, H.; Buchholz, R.:
    Optimization of the manufacture of sodium cellulose sulfate (NaCS) for the microencapsulation of cell cultures.
    Chemie Ingenieur Technik 74(3) (2002), 359-363.
     
  99. Orakci, O.; Hübner, H.; Buchholz, R.:
    UV-Blocker für Viren.
    Poster Friedrich-Alexander-Universität Erlangen-Nürnberg (2002), 359-363.
     
  100. Bohlmann, J.T.; Schneider, C.; Andresen, H.; Buchholz, R.:
    Optimized production of sodium cellulose sulfate (NaCS) for microencapsulation of cell cultures.
    Engineering Life Sciences 2(12) (2002), 384-388.
     
  101. 2001
     
  102. Yalcin, E.; Kloth, C.; Buchholz, R.; Emmrich, F.; Harnisch, J.; Lemke, U.; Gerlach, J.; Marx, U.:
    Increased production yields of native interferon in membrane bioreactors by continuous harvest.
    Animal Cell Technology: From Target to Market
    Proceedings of the 17th ESACT Meeting, Tyl�sand, Schweden (2001), 389-392.
     
  103. Klimmek, S.; Stan, H. - J.; Wilke, A.; Bunke, G.; Buchholz, R.:
    Characterization of the Biosorption of Cadmium, Lead, Nickel and Zinc by Algae.
    Environmental Science & Technology 35(21) (2001), 4283-4288.
     
  104. Klimmek, S.; Stan, H.-J.; Wilke, A.; Bunke, G.; Buchholz, R.:
    Comparative analysis of the biosorption of cadmium, lead, nickel, and zinc by algae.
    Environmental Science & Technology 35(2001), 4238-4288.
     
  105. Bettermann, A.; Buchholz, R.; Hübner, H.; Schneider, C.:
    Particulate construct for use in the transplantation field.
    PCT Int. Appl. (2001), 24 pp.
     
  106. Walter, C.; Buchholz, R.:
    Development of culture techniques for the production of valuable chemicals from microalgae by the example of docosahexaenoic acid.
    Proceedings 8. Seminar Verfahrenstechnik, Miskolc, Ungarn (2001).
     
  107. Walter, C.; Buchholz, R.:
    Entwicklung eines Verfahrens zur Gewinnung von Docosahexaensäure mit aquatischen Mikroorganismen unter Einsatz von Licht und organischen Substraten.
    19. DECHEMA-Jahrestagung der Biotechnologen, Leipzig (2001), 87-88.
     
  108. 2000
     
  109. Bettermann, A.; Schneider, C.; Hübner, H.; Buchholz, R.; Wit, J.; Kage, A.; Salomon, A.; Graffstädt, H.:
    Mikrokapseln aus Fibrin zur Kultivierung von humanen Hautzellen.
    Ellipse (2000) 2, 37-42.
     
  110. Janelt, G.; Gerbsch, N.; Buchholz, R.:
    A novel fiber optic probe for online monitoring of biomass concentrations.
    Bioprocess and Biosystems Engineering 22 (2000), 275-279.
     
  111. Srivastava, P.; Hahr, O.; Buchholz, R.; Worden, R.M.:
    Enhancement of mass transfer using colloidal liquid aphrons: Measurement of mass transfer coefficents in liquid-liquid extraction.
    Biot. Bioeng. 70 (2000) 5, 525-532.
     
  112. Wilke, A.; Bunke, G.; Buchholz, R.:
    Heavy metal adsorption using immobilized microalgae.
    Biologische Abwasserreinigung 13 (Sorptionsverfahren der Wasser- und Abwasserreinigung (2000) 5, 133-150.
     
  113. Wilke, A.; Bunke, G.; Buchholz, R.:
    Selective removal of heavy metals from the aqueous phase by the process of biosorption.
    Biologische Abwasserreinigung 14 (2000) 5, 229-246.
     
  114. Wilke, A.; Bunke, G.; Götz, P.; Buchholz, R.:
    Individual biomass supports for metals removal from wastewaters.
    Deutsche Offenlegungsschrift (2000) 5, 6 pp.
     
  115. Buchholz, R.; Hübner, H.:
    A process for the continuous production of viruses and/or recombinant proteins.
    Ger., 8 pp. (2000).
     
  116. Buchholz, R.; Hübner, H.:
    Continuous preparation of pathological viruses or recombinant proteins comprising infecting cells kept within a hollow sphere within a vessel while providing the cells with nutrients.
    Patent (2000).
     
  117. Dörnenburg, H.; Buchholz, R.:
    Bioactive metabolites from micro and macro algae.
    Proceed. Internat. Seminar on Bioindustry, East Coastal Marine Bioresources Research Center, Kangnung, Korea (2000).
     
  118. Gerbsch, N.; Rarbach, M.; Walter, C.; Buchholz, R.:
    Photobioreactors for the Monoseptic Cultivation of Microalgae.
    Proceed. 4th European Workshop in Biotechnology of Microalgae, Potsdam (2000).
     
  119. 1999
     
  120. Bohlmann, J.; Lorth, C.; Drews, A.; Buchholz, R.:
    Microwave high pressure thermochemical conversion of sewage sludge as an alternative to incineration.
    Chem. Eng. Technol. 21 (1999) 5, 404-409.
     
  121. Yu, S.-H.; Buchholz, R.; Kim, S.-K.:
    Encapsulation of rat hepatocyte spheroids for the development of artificial liver.
    Biot. Techniques 13 (1999), 609-614.
     
  122. Bunke, G.; Götz, P.; Buchholz, R.:
    Metal Removal by Biomass - Physico-Chemical Elimination Methods, Environmental Process - Waste and Waste Water Treatment.
    Vol. 11a of the series: Biotechnology, 2nd Edition, Series Editors: Rehm, H.J.; Reed, G.; Pühler, A.; Stadtler, P.; Kapitel 23 (1999), 1-22.
     
  123. Wilke, A.; Bunke, G.; Götz, P.; Buchholz, R.:
    Removal of Lead, Cadmium, Zinc and Nickel by Adsorption on Microalgae.
    Progress in Mining and Oil Field Chemistry, Challenges of an Interdisciplinary Science - Akademiai Kiado, Budapest (1999), Vol. 1, 337 - 344.
     
  124. Maerz, H.; Buchholz, R.; Emmerich, F.; Fink, F.; Pfeifer, L.; Raabe, F.; Scheper,T.; Marx. U.:
    Applicating Fibre Optical Methods for Toxicological Testing in Vitro.
    Proceedings of the SPIE s BIOS `99, San Jose, Ca, USA 1999, Vol. 3603, 228-239.
     
  125. Maerz, H.; Buchholz, R.; Emmerich, F.; Fink, F.; Pfeifer, L.; Raabe, F.; Marx, U.:
    Monitoring Tissue Metabolism via Time-Resolved Laser Fluorescence.
    Proceedings of the SPIE s BIO '99, San Jose, Ca, USA 1999, Vol. 3602, 24-35.
     
  126. Hübner, H.; Buchholz, R.:
    Microencapsulation.
    In: M.C. Flickinger, S. W. Drew (eds.): Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis and Bioseparation: John Wiley & Sons, Inc. New York (1999), ISBN 0-471-13822-3, 1785-1798.
     
  127. Maerz, H.; Buchholz, R.; Emmerich, F.; Fink, F.; Pfeifer:
    Monitoring drug effect on human primary tissues utilizing fibre optical sensors.
    Animal Cell Technology: Basic & Applied Aspects Part 13, Proceedings of the Annual Meeting of the Japanese Association for Animal Cell Technology, 10th, Nagoya, 5-8 November (1999), 165-169.
     
  128. Bunke, G.; Götz, P.; Buchholz, R.:
    Metal Removal by Biomass - Physico-Chemical Elimination Methods.
    Environmental Process - Waste and Waste Water Treatment. Vol. 11a of the series: Biotechnology, 2nd Edition, Series Editors Rehm, H.J.; Reed, G.; Pühler, A.; Stadtler, P. (1999), Kapitel 23, 1-22.
     
  129. Garbe, L.-A.; Lange, H.A.; Haffner, T.; Tressl, R.:
    Biosynthesis of Optically Active Z-6-Dodecen-4-4-olide by Lipoxygenase or Peroxygenase - Pathways in the Yeast Sporobolomyces odorus.
    Posterpresentation: 9th Weurman Flavor Research Symposium, Freising, Germany, 22-25 June (1999).
     
  130. Kloth, C.; Leibiger, H.; Valley, U.; Yalcin, E.; Buchholz, R.; Emmrich, F.; Marx, U.:
    Glycosylation Analysis of Nanomolar Amounts of Glycoprotein Combining In-Gel Enzymatic Digestion and FACE(TM).
    In: A. Bernard et al. (Hrsg): Animcal Cell Technology: Products from Cells, Cells as Products. Dordrecht: Kluwer Academic Publishers (1999), 237-239.
     
  131. Tressl, R.; Garbe, L.-A.; Lange, H.A.:
    Biosynthesis of Optically Active Lactones by Lipoxygenase/Peroxygenase Pathways in Yeast.
    Posterpresentation: 9th Weurman Flavor Research Symposium, Freising, Germany, 22-25 June (1999).
     
  132. Tressl, R.; Garbe, L.-A.; Lange, H.A.:
    Biosynthesis of gamma-Nonalactone in Yeast.
    Posterpresentation: 218th National Meeting of the American Chemical Society, New Orleans, U.S.A. 22-26 August (1999).
     
  133. Tressl, R.; Garbe, L.-A.; Lange, H.A.:
    Biosynthesis of gamma-Nonalactone in Yeast.
    Abstracts of Papers of the American Chemical Society 218: U27 - Proceedings (1999).
     
  134. Buchholz, R.; Gerbsch, N.; Walter, C.; Steinau, T.:
    Bioreactor with U-shaped reactor elements.
    Ger., 12 pp. (1999)
     
  135. Dieckmann, M.; Buchholz, R.:
    Apparatus for measuring the partial pressure of gases dissolved in liquids.
    U.S. (1999)
     
  136. Eberle, A.; Hübner, H.; Buchholz, R.; Schroedter, M.:
    Microcapsules for immobilizing biocatalysts.
    Deutsche Offenlegungsschrift, 10 pp. (1999)
     
  137. Buchholz, R.; Gerbsch, N.; Walter, C.; Steinau, T.:
    Pat. EP D 911 386, 28.1.1999 (Patent) (1999).
     
  138. 1998
     
  139. Maerz, H.; Buchholz, R.; Emmerich, F.; Fink, F.; Pfeifer.:
    Monitoring Drug Effects on Human Primary Tissues Utilizing Fibre Optical Sensors - A Human Model in vitro.
    (1998).  
  140. Gerbsch, N.; Rarbach, M.; Walter, C.; Buchholz, R.:
    Fiberoptic and Tubular Photobioreactor for Monoseptic Cultivation of Microalgae.
    Marine Bioprocess Engineering, Noordwijkerhout 1998.
     
  141. Wilke, A.; Bunke, G.; Götz, P.; Buchholz, R.:
    Removal of Heavy Metal Ions from Waste Water by Adsorption on Microalgae.
    Sixth Symposium on Mining Industry, 27-30 September, Siofok, Hungary 1998, 113-336.
     
  142. Maerz, H.; Buchholz, R.; Emmerich, F.; Fink, F.; Pfeifer, L.; Marx, U.: Development of a Pharmacological Test System in a Miniaturized Hollow Fiber Reactor Technology.
    Proceedings of the 1st International Conference on Microreaction Technology
    Ehrfield, W. (Ed.), Germany 1998, 256-266.
     
  143. Kim, S.-K.; Yu, S.-H.; Son, J.-H.; Hübner, H.; Buchholz, R.:
    Calculations on O2 transfer in capsules with animal cells for the determination of maximum capsule size without O2 limitations.
    Biotech. Letters 20 (1998) 6, 549-552.
     
  144. Tressl, R.; Garbe, L.-A.; Lange, H.; Haffner, T.:
    Biosynthesis of (R)-5-decanolide by 13-lipoxygenase and 13-hydroxylase pathways in the yeast Sporobolomyces odurus.
    Abstracts of Papers of the American Chemical Society 216, U46-U46 (1998).
     
  145. Worlitschek, J.; Hübner, H.; Buchholz, R.:
    Continuous production of paclitaxel by encapsulated cell culture.
    In Vitro Cellular and Development Biology Animal 34: 64A (1998).
     
  146. Walter, C.; Buchholz, R.:
    Entwicklung und Scale-up eines Photobioreaktors.
    Chemie-Ingenieur-Technik 70 (1998), 1123.
     
  147. Hübner, H.; Buchholz, R.:
    Production of baculovirus by microencapsulation.
    In Vitro Cellular and Developmental Biology Animal 34: 41A (1998).
     
  148. Joo, D.-S.; Cho, M.-G.; Buchholz, R.; Lee, E.-H.:
    Growth and fatty acid composition with growth conditions for Spirulina platensis.
    Han'guk Susan Hakhoechi, 31(3)(1998), 409-416.
     
  149. Lorth, C.M.; Bohlmann, J.T.; Buchholz, R.:
    Thermochemische Umwandlung von Biomassenabfällen in einem neuartigen Mikrowellen-Hochdruck-Reaktor.
    Chemie Ingenieur Technik 70(9) (1998), 1155-1156.
     
  150. Maerz, H.; Buchholz, R.; Emmrich, F.; Pfeiffer, L.; Marx, U.:
    Development of a pharmacological test system in a miniaturized hollow fiber bioreactor.
    Microreaction Technology, Proceedings of the International Conference on Microreaction Technology 1997, Proceedings (1998), 259-266.
     
  151. Schneider, C.; Hübner, H.; Buchholz, R.:
    Cultivation of human skin cells in microcapsules.
    In Vitro Cellular and Development Biology Animal 34: 30A (1998), 259-266.
     
  152. Schroedter, M.; Buchholz, R.:
    Use of semipermeable polymer membranes in biotechnological in situ extraction processes.
    Chemie Ingenieur Technik 70(12) (1998), 1617-1619.
     
  153. Schulz, H.; Throm, K.; Hübner, H.; Buchholz, R.:
    A novel human hepatocyte cell line for application in in vitro assays to prevent animal tests.
    In Vitro Cellular and Developmental Biology Animal 34: 39A (1998).
     
  154. Buchholz, R.; Ramirez, S.:
    Conversion of organic materials into fuels.
    Patent (1998).
     
  155. Buchholz, R.; Ramirez, S.:
    Production of fuels and chemical raw materials from biological residues and wastes.
    Deutsche Offenlegungsschrift (1998), 6 pp.
     
  156. 1997
     
  157. Hübner, H.; Buchholz, R.:
    High density cultivation of insect cells in micro hollowspheres.
    In: Maramorosch, K., Mitsuhashi, J. (Eds.): Invertebrate cell culture - Novel directions and biotechnology applications Part 4: Advances in cell technologies, Science Publisher Inc. (1997) ISBN 1-57808-011-8, 123-130.
     
  158. Prötzl, B.; Buchholz, R.:
    Entwicklung einer Anlage zur Herstellung von Natriumcellulosesulfaten und Optimierung der Prozessführung.
    Internet Veröffentlichung
    http://www.tu-berlin.de/~biotec/BVT/Onlinpub.html
    (1997).
     
  159. Eichenmüller, B.; Behrendt, C.; Bunke, G.; Buchholz, R.; Götz, P.:
    Adsorption of acenaphtlene on porous organic polymers.
    Journal of Environmental Engineering, Vol. 123, No. 9 (1997) 836 - 841.
     
  160. Preissmann, A.; Wiesmann, R.; Buchholz, R.; Werner, R.G.; Noe, W.:
    Investigations on oxygen limitations of adherent cells growing on macroporous microcarriers.
    Cytotechnology 24 (1997) 2, 121-134.
     
  161. Janelt, G.; Bolt, P.; Gerbsch, N.; Buchholz,R.:
    The Lamellar settler - a low-cost alternative for separating the micro-alga Chlorella vulgaris from a cultivation broth?
    Appl. Microbiol. Biotechnol. 48 (1997) 1, 6-10.
     
  162. Buchholz, R.; Cho, M.; Gerbsch, N.; Rarbach, M.; Walter, C.:
    Biotechnologie mit Mikroalgen.
    TU International. 6/37 (1997).
     
  163. Buchholz, R.; Gerbsch, N.; Janelt, G.; Kreitel, M.:
    Procedure and device for the optical measurement of particle sand materials in fluids (Machine Translation).
    Deutsche Offenlegungsschrift (1997).
     
  164. Buchholz, R.; Gerbsch, N.; Janelt, G.; Kreitel, M.:
    Verfahren und Vorrichtung zur optischen Messung von Partikeln und Stoffen in Fluiden.
    Deutsche Offenlegungsschrift (1997).
     
  165. Hübner, H., Buchholz, R.:
    High density cultivation of insect cells in micro hollowspheres.
    In: Maramorosch, K., Mitsuhashi. J., (Eds.): Invertebrate cell culture - novel directions and biotechnology applications. Part 4: Advances in cell technologies. Science Publisher Inc. (1997) ISBN 1-57808-011-8, 123-130.
     
  166. 1996
     
  167. Eichenmüller, B.; Bunke, G.; Buchholz, R.; Götz, P.:
    Adsorptionsverfahren zur Abtrennung von PAK aus Abwässern und Möglichkeiten der Adsorbensregenerierung.
    Biologische Abwasserreinigung 7: Biologische und chemische Behandlung von PAK-haltigen Böden und Abwässern, Schriftenreihe des Sonderforschungsbereichs 193 der Technischen Universität Berlin
    (Redaktion: M. Cuno) (1996) 299 - 310.
     
  168. Götz, P.; Eichenmüller, B.; Bunke, G.; Buchholz, R.:
    Selektive Adsorption von PAK an oxidativ regenerierbaren Adsorbentien.
    Stegmann (Hrsg.) : Neue Techniken der Bodenreinigung 101 - 112, Economica Verlag , Bonn 1996.
     
  169. Zalewski, K.; Buchholz, R.:
    Morphological analysis of yeast cells using an automated image processing system.
    Journal of Biotechnology, 48 (1996), 43-49.
     
  170. Buchholz, R.:
    Survey of the actual status of PAH treatment in contaminated soils and wastewaters.
    Biologische Abwasserreinigung 7 (Biologische und Chemische Behandlung von PAK-haltigen Böden und Abwässern (1996), 3-13.
     
  171. Dieckmann, M.; Buchholz, R.:
    Gas partial pressure measuring point in contact with boundary layer of light-conductor.
    Patent (1996).
     
  172. Dieckmann, M.; Buchholz, R.:
    Device for measuring the partial pressure of gases dissolved in liquids.
    Deutsche Offenlegungsschrift (1996), 7 pp.
     
  173. Krueger, M.; Buchholz, R.:
    Biotechnology, Vol. 9, Enzymes, Biomass, Food and Feed by H.-J. Rehm and G. Reed (Buchbesprechung).
    Chemie Ingenieur Technik 68(8) (1996), 985.
     
  174. Tressl, R.; Haffner, T.; Lange, H.A.; Nordsiek, A.:
    Formation of y- and d-lactones by different biochemical pathways.
    Flavour Science (Eds. P. Schieberle; K.-H. Engel) The Royal Society of Chemistry, Cambridge (1996).
     
  175. Hübner, H.; Wiesmann, R.; Schroedter, M.; Buchholz, R.:
    High density cultivation of insect cells in micro hollowspheres.
    IN VITRO Cellular & Developmental Biology, Vol. 32, Nr. 3, Part II (1996) 39 A-40 A.
     
  176. 1995
     
  177. Pulz, O.; Gerbsch, N.; Buchholz, R.:
    Light Energy Supply in Plate-Type and Light Diffusing Optical Fiber Bio- reactors.
    Journal of Applied Phycology (1995) 7, 145-149.
     
  178. Gerbsch, N.; Buchholz, R.:
    New Processes and Actual Trends in Biotechnology.
    FEMS Microbiology Reviews 16 (1995), 259 - 269.
     
  179. Maier, S.-T.; Buchholz, R.; Marx, U.:
    Influence of Glucose, Glutamine and Oxygen on the Metabolism of Hybridomas and Peripheral Blood Cells.
    I n: Beuvery, E. C.; Griffiths, J. B.; Zeijlemaker, W. P.; Animal Cell Technology (1995), 235-239.
     
  180. Kloth, C.; Riese, C.; Cho, M.-G.; Buchholz, R.; Marx, U.:
    Mab Production and Treatment of Rheumaoid Disease using Encapsulated Anti-Idiotypic Hybridoma Cells.
    I n: Beuvery, E. C.; Griffiths, J. B.; Zeijlemaker, W. P.; Animal Cell Technology (1995), 765-769.
     
  181. Eichenmueller, B.; Goetz, P.; Bunke, G.; Buchholz, R.:
    Elimination of polycyclic aromatic hydrocarbons by adsorptive and microbial processes.
    Biochemical Engineering 3, International Symposium on Biochemical Engineering, 3rd, Stuttgart, Mar. 6-8 (1995), Proceedings.
     
  182. Kiehne, M.; Berghof, K.; Mueller-Kuhrt, L; Buchholz, R.:
    Mobile revolving tubular reactor for continuous microbial soil decontamination.
    Soil & Environment, 5 (Contaminated Soil 95, Vol.2) (1995), 873-882.
     
  183. Pulz, O.; Buchholz, R.; Franke, H.; Gerbsch, N.; Scheibenbogen, K.:
    Procedures and device for illuminate from media (Machine Translation).
    Deutsche Offenlegungsschrift(1995).
     
  184. Pulz, O.; Buchholz, R.; Franke, H.; Gerbsch, N.; Scheibenbogen, K.:
    Process and appts. for generating phototrophic cultures and reactions.
    Patent(1995).
     
  185. Buchholz, R.; Fricke, U.; Mixich, J.:
    Process for preparing purified glycolipids by membrane separation processes.
    United States Patent 5,440,028
    Official Gazette of the United States Patent and Trademark Office Patents 1177, 1053 (1995).
     
  186. 1994
     
  187. Zalewski, K.; Götz, P.; Buchholz, R.:
    Online estimation of yeast growth rate using morphological data from image analysis.
    Advances in Bioprocess Engineering, Kluwer Academic Publishers, Dordrecht (1994).
     
  188. Wiesmann, R.; Götz, P.; Buchholz, R.:
    Measurement and Modelling of Oxygen Transport into Biotechnical Immobilisates for Cell Entrapment.
    Adv. in Bioprocess Engineering (1994), 217 -220.
     
  189. Wiesmann, R.; Maier, S.-T.; Marx, U.; Buchholz, R.:
    Characterization of oxygen transfer in a membrane aerated hollow fiber bioreactor using microelectrodes.
    Appl. Microbiol. Biotechnol. (1994) 41, 531 - 536.
     
  190. Wiesmann, R.; Zimelka, W.; Baumgärtl, H.; Götz, P.; Buchholz, R.:
    Investigation of oxygen transfer through the membrane of polymer hollowspheres by oxygen microelectrodes.
    Journal of Biotechnology 32 (1994), 221 -229.
     
  191. Zalewski, K.; Goetz, P.; Buchholz, R.:
    On-line estimation of yeast growth rate using morphological data from image analysis.
    Adv. Bioprocess Eng. (1994), 191-195.
     
  192. 1993
     
  193. Cho, M.-G.; Buchholz, R.:
    Verfahrenstechnische Auslegung einer Apparatur zur Herstellung mikroverkapselter Biokatalysatoren.
    Chem.-Ing.-Tech. 65 (1993) 10, 1221-1223.
     
  194. Kiehne, M.; Müller-Kuhrt, L.; Berghof, K.; Buchholz, R.:
    Kontinuierlicher Drehrohrreaktor zur Bodensanierung.
    Chem.-Ing.-Technik 65 (1993) 11, 1343 - 1345.
     
  195. Cho, M.-G.; Buchholz, R.:
    Verfahrenstechnische Auslegung einer Apparatur zur Herstellung mikroverkapselter Biokatalysatoren mit getrennter ZufÜvon Katalysatorlösung und Kapselgrundsubstanz.
    Chemie Ingenieur Technik 65(9) (1993), 1125-1126.
     
  196. Yao, M.S.S.; Cho, M.-G.; Buchholz, R.:
    Umweltfreundliches Herstellungsverfahren von Cellulosesulfat für die Immobilisierung von Mikroorganismen und Enzymen in der Biotechnik.
    Chemie Ingenieur Technik 65(9) (1993), 1124-1125.
     
  197. 1992
     
  198. Zalewski, K.; Hantsche, R.; Buchholz, R.:
    Biomassemessung im Durchfluß-Mikroskop.
    Chemische Rundschau Nr. 35, Jahrgang 45, September 1992.
     
  199. Buchholz, R.:
    Der Bioreaktor als Lebensraum für die biotechnische Produktion von Wertstoffen.
    Biologie in unserer Zeit 22 (1992) 6, 353-355.
     
  200. Buchholz, R.:
    Environments - life forms. The bioreactor as an environment in the biotechnical production of substances.
    Biologie in unserer Zeit 22 (6) (1992), 353-355.
     
  201. Buchholz, R.:
    Method and device for soil decontamination.
    Eur. Pat. Appl. (1992).
     
  202. Buchholz, R.; Fricke, U.; Mixich, J.:
    Production of purified glycolipids by a membrane separation method.
    PCT Int. Appl. (1992), 13 pp.
     
  203. Buchholz, R.:
    Biotechnik - eine alte und neue Technik.
    In: Jahrhundertwissenschaft Biologie ?! (Herausgeber: P. Präve)
    VCH Verlagsgesellschaft, Weinheim 1992.
     
  204. 1991
     
  205. Buchholz, R.:
    Methoden zur Charakterisierung des dynamischen Verhaltens von Gas/Flüssigkeits-Mehrphasenströmungen.
    DECHEMA-Monographien 107, VCH Verlagsgesellschaft 1987 und
    Chem. Eng. Technol. 14 (1991), 127-134.
     
  206. Buchholz, R., Hoffmann H.M.R.:
    αMethylidene and α-Alkylidene-β-lactams from Nonproteinogenic Amino Acids.
    Helvetica Chimica Acta 74(1991), 1213-1220.
     
  207. Markl, H.; Wiesmann, U.; Kasche, V.; Buchholz, R.:
    Biotechnology.
    Chemie Ingenieur Technik 63 (1991), 1213-1216.
     
  208. Schäfer, H.; Bayer, Th.; Buchholz, R.; Kühlein, K.; Schlingmann, M.; Wullbrandt, D.:
    A New Process for Indirect Gas Supply by Means of Perfluorinated Polyethers.
    Chemical Engineering & Technology 14 (1991), 127-134.
     
  209. 1990
     
  210. Buchholz, R.; Giani, C.; Fricke, U.; Rüppel, D.; Walch, A.; Bayer, T.; Kurrle, R.; Krause, D.; Lang, W.; Reiche, A.:
    Verfahren zur Kultivierung von Zellen in Mikrohohlkugeln.
    Patent(1990).
     
  211. 1989
     
  212. Rustemeyer, U.; Pauli, J.; Menzel, T.; Buchholz, R.; Onken, U.:
    Liquid-Phase Mixing Model for Hydrodynamics of Bubble Columns.
    Chem. Eng. Process. 26 (1989), 165-172.
     
  213. Bayer, T.; Buchholz, R.; Deger, H.M.; Wink, J.:
    Verfahren zur Herstellung von Farbstoffen und/oder Wirkstoffen in der wasserarmen, sterilen Wirbelschicht.
    EU Patent (1989).
     
  214. Buchholz, R.; Schaefer, H.; Schlingmann, M.; Siegemund, G.; Walch, A.; Wullbrandt, D.:
    Procedure for the exhaust-free aeration of fermentation media (Machine Translation).
    Deutsche Offenlegungsschrift (1989).
     
  215. Then, J.; Giani, C.; Woehner, G.; Wink, J.; Buchholz, R.; Voelskow, H.; Schlingmann, M.; Rapp, K.; Vogel, M.:
    Preparation and use of polysaccharides containing rhamnose.
    Eur. Pat. Appl. (1989), 8 pp..
     
  216. 1988
     
  217. Buchholz, R.; Deger, H.; Voelskow, H.; Woernle, R.:
    Sterilisierbarer Wirbelschichtfermenter.
    EU Patent(1988).
     
  218. Buchholz, R.; Deger, H.; Voelskow, H.; Woernle, R.:
    Sterilizable fluidized bed fermenter.
    United States Patent 4,746,615.
    Official Gazette of the United States Patent and Trademark Office Patents 1090, 1971 (1988).
     
  219. Buchholz, R.; Deger, H.; Voelskow, H.; Woernle, R.:
    Sterilize-cash fluidized bed fermenter (Machine Translation).
    Deutsche Offenlegungsschrift (1988).
     
  220. Gawlik, D.; Gatschke, W.; Buchholz, R.; Jacob, G.; Klein, J.; Rose, M.; Truong, Q.V.:
    The design of a fast pneumatic transfer system in consideration of the security demands of a modern research reactor.
    Journal of Trace and Microprobe Techniques 6(2) (1988), 161-179.
     
  221. 1987
     
  222. Buchholz, R.:
    Measurement methods for characterization of the behavior of multi-phase gas/liquid flows.
    DECHEMA Monographien, 107 (Fortschr. Sicherheitstechn. 1) VCH Verlagsgesellschaft (1987), 169-197.
     
  223. Buchholz, R..:
    Methoden zur Charakterisierung des dynamischen Verhaltens von Gas/Flüssigkeits-Mehrphasenströmungen.
    DECHEMA Monographien, 107, VCH Verlagsgesellschaft (1987), 169-197.
     
  224. Fellensiek, J.; Buchholz, R.; Onken, U.; Overhoff, K.H.; Schecker, H.G.:
    Tauchvorlagen als Zündsicherungen in Abgasleitungen von Chemieanlagen (Immersion Traps as Incineration Protection in Exhaust Gas Pipelines in Chemical Plants).
    DECHEMA Monographien, 107, VCH Verlagsgesellschaft (1987), 199-218.
     
  225. Fellensiek, J.; Buchholz, R.; Onken, U.; Overhoff, K.H.; Schecker, H.G.:
    Water trap flame arrestors in waste gas conduits of chemical plants.
    DECHEMA Monographien, 107, VCH Verlagsgesellschaft (1987), 199-218.
     
  226. Koch, A.; Traeger, M.; Weiland, P.; Buchholz, R.; Onken, U.:
    Measurement and modeling of mass transfer in an airlift loop reactor with regard to reactor design.
    Chemie Ingenieur Technik 59(12) (1987), 964-965.
     
  227. Koch, A.; Weiland, P.; Buchholz, R.; Onken, U.:
    Messung und Modellierung der Hydrodynamik von Airlift-Schlaufenreaktoren.
    Chemie Ingenieur Technik 59(12) (1987), 962-963.
     
  228. Rustemeyer, U.; Onken, U.; Buchholz, R.:
    Ein neues Vermischungsmodell für die flüssige Phase in Blasensäulen.
    Chemie Ingenieur Technik 59(12) (1987), 613.
     
  229. 1986
     
  230. Riethues, M.; Buchholz, R.; Onken, U.; Baumgärtl, H.; Lübbers, D. W.:
    Determination of Oxygen Transfer from Single Air Bubbles to Liquids by Oxygen Microelectrodes.
    Chem. Eng. Process. 20 (1986), 331-337.
     
  231. Buchholz, R.; Fellensiek, J.; Overhoff. K.-H.; Schecker, H. G.; Onken, U.:
    Untersuchungen zur Entwicklung einer Zündsperre mit Schlaufengeometrie.
    Chem.-Ing.-Tech. (1986).
     
  232. Sobolik, V.; Buchholz, R.; Onken, U.:
    Hot-Wire Anemometry in Highly Viscous and Non-Newtonian Liquids.
    Sammelschrift des Symposiums "Anemometry" (1986) in Bratislava.
     
  233. Fellensiek, J.; Overhoff, K.H.; Schecker, H.G.; Onken, U.:
    Studies of the development of an ignition arrestor with loop geometry.
    Chemie Ingenieur Technik 58(11)(1986), 912-913
     
  234. Fellensiek, J.; Overhoff, K.H.; Schecker, H.G.; Onken, U.:
    Untersuchungen zur Entwicklung einer Zündsperre mit Schlaufengeometrie.
    Chemie Ingenieur Technik 58 (1986), 912-913
     
  235. Yang, Z.; Rustemeyer, U.; Buchholz, R.; Onken, U.:
    Profile of liquid flow in bubble columns.
    Chemical Engineering Communications 49(1-3) (1986), 51-67
     
  236. 1985
     
  237. Onken, U.; Buchholz, R.; Riethues, M.; Lübbers, D. W.; Baumgärtl, H.:
    Stoffübergangsmessungen an Einzelblasen mittels Sauerstoff-Mikrosonden.
    Chem.-Ing.-Tech. 57 (1985), 857-859.
     
  238. Onken, U.; Buchholz, R.; Sittig, W.:
    Measurement and Instrumentation.
    In Biotechnology, Vol. 2 (Ed. Rehm, H.-J., Reed, R.) 29, VCH Verlagsgesellschaft, Weinheim 1985, 765-786.
     
  239. Franz, K.; Menzel, T.; Kantorek, H.-J.; Buchholz, R.:
    Einfluß der Reaktorgeometrie und des Gasverteilers auf das Strömungsbild in Blasensäulen.
    Chem.-Ing.-Tech. 57 (1985), 474-475.
     
  240. Steinemann, J.; Buchholz, R.:
    Leitfähigkeits-Mikrosonden zur Charakterisierung von Gas-/Flüssigströmungen.
    Chemie-Technik 14 (1985), 146-153.
     
  241. Menzel, T.; Kantorek, H.-J.; Franz, K.; Buchholz, R.; Onken, U.:
    Zur Strömungsstruktur in Airlift-Schlaufenreaktoren.
    Chem.-Ing.-Tech. 57 (1985), 139-141.
     
  242. Menzel, T.; Kantorek, H.-J.; Franz, K.; Buchholz, R.; Onken, U.:
    Flow structure in air-lift loop reactors.
    Chemie Ingenieur Technik 57(2) (1985), 139-141.
     
  243. Riethues, M.; Baumgartl, H.; Buchholz, R.; Onken, U.; Lubbers, D.W.:
    Oxygen transfer from gas bubble into liquid. Advances in experimental medicine and biology.
    191 (1985), 955-964.
     
  244. Schäfer-Treffenfeldt, W.; Engel, R.; Onken, U.; Buchholz, R.:
    Mikrobielle Oxidation von Schwefelwasserstoff aus Industrieabgasen.
    Chemie Ingenieur Technik 57(1985), 712-713.
     
  245. 1984
     
  246. Riethues, M.; Baumgärtl, H.; Buchholz, R.; Onken, U.; Lübbers, D. W.:
    Oxygen Transfer from Gas Bubble into Liquid.
    Proceedings of the ISOTT -Meeting, Nijmegen 1984, 26-30/8.
     
  247. Steinemann, J.; Buchholz, R.:
    Application of an Electrical Conductivity Microprobe for the Characterization of Bubble Behaviour in Gas-Liquid Bubble Flow.
    Part. Charact. 1 (1984), 102-107.
     
  248. Franz, K.; Börner, T.; Kantorek, H.-J.; Buchholz, R.:
    Strömungsstruktur in Blasensäulen.
    Chem.-Ing.-Tech. 56 (1984), 154-155; VDI-Berichte 545 (1984), 997-1023.
     
  249. Franz, K.; Börner, T.; Kantorek, H.-J.; Buchholz, R.:
    Flow Structures in Bubble Columns.
    Ger. Chem. Eng. 6 (1984), 365-374.
     
  250. Franz, K.; Börner, T.; Kantorek, H.-J.; Buchholz, R.:
    Flow Structures in Bubble Columns.
    Chemie Ingenieur Technik 56(2) (1984), 154-5.
     
  251. Onken, U.; Buchholz, R.; Schaefer, W.:
    Microorganisms and method for removing hydrogen sulfide from gases or liquids.
    Deutsche Offenlegungsschrift(1984), 12 pp.
     
  252. 1983
     
  253. Buchholz, R.; Tsepetonides, J.; Steinemann, J.; Onken, U.:
    Influence of Gasdispersion on Interfacial Area and Mass Transfer in Bubble Columns.
    Ger. Chem. Eng. 6 (1983), 105-113.
     
  254. Buchholz, R.; Franz, K.; Onken, U.:
    Entwicklung einer richtungscharakteristischen Messtechnik zur Bestimmung der turbulenten Strömungsstruktur in Mehrphasenströmungen.
    VDI-Berichte 470 (1983), 580-598.
     
  255. 1982
     
  256. Buchholz, R.; Tsepetonides, J.; Steinemann, J.; Onken, U.:
    Einfluß des Begasers auf die spezifische Phasengrenzfläche und den Stofftransport in Blasensäulen.
    Chem.-Ing.-Tech. 54 (1982), 840-841.
     
  257. Buchholz, R.; Franz, K.; Onken, U.:
    Entwicklung einer richtungscharakteristischen Meßtechnik zur Bestimmung der turbulenten Strömungsstruktur in Mehrphasenströmungen.
    Chem.-Ing.-Tech. 54 (1982), 608-609; VDI-Berichte 470 (1983), 580-598.
     
  258. Onken, U.; Buchholz, R.:
    Meßmethoden in Fermentern unter sterilen Bedingungen.
    Chem.-Ing.-Tech. 54 (1982), 581-590.
     
  259. Buchholz, R.; Franz, K.; Onken, U.:
    Development of a directionally characteristic measuring technique for determining the turbulent flow structure in multiphase flows.
    Chemie Ingenieur Technik 54(6) (1982), 608-9.
     
  260. Steinemann, J.; Baumgartl, H.; Onken, U.:
    Investigation of the 2 phase flow in bubble columns and loop bioreactors with a 4-point conductivity micro-probe.
    Chemische Technik 34 (1982), 337.
     
  261. Frank, K.; Boerner, T.; Buchholz, R.:
    Investigation of turbulence properties in 2-phase bubble flow.
    Chemische Technik 34(1982), 337.
     
  262. 1981
     
  263. Buchholz, R.; Zakrzewski, W.; Schügerl, K.:
    Techniques for Determining the Properties of Bubbles in Bubble Columns.
    Int. Chem. Eng. 21 (1981), 180-187.
     
  264. 1980
     
  265. Börner, T.; Franz. K.; Buchholz, R.:
    Eichprobleme bei der Anwendung der Heißfilm-Anemometertechnik zur Bestimmung von Turbulenzgrößen in Zweiphasenströmungen.
    Chem.-Ing.-Tech. 52 (1980), 764-765.
     
  266. Franz, K.; Buchholz, R.; Schügerl, K.:
    Comprehensive Study of the Gas Hold Up and Bubble Size Distribution in Highly Viscous Liquids I. Glycerol Solutions II. C M C Solutions.
    Chem. Eng. Commun. 5 (1980), Part I: 165-186; Part II: 187-202.
     
  267. 1979
     
  268. Buchholz, R.:
    Untersuchung der Struktur der Mehrphasenströmung in Blasensäulen-Bioreaktoren.
    Dissertation, Universität Hannover 1979.
     
  269. Buchholz, R.; Zakrezewski, W.; Schügerl, K.:
    Meßtechniken zur Bestimmung der Eigenschaften von Blasen in Blasensäulen.
    Chem.-Ing.-Tech. 51 (1979), 568-575.
     
  270. Buchholz, R.; Adler, I.; Schügerl, K.:
    Investigation of the Structure of Two-Phase Flow Model-Media in Bubble Column Bioreactors.
    I.Transverse Variation of Local Properties when Coales-cence-Promoting Media Are Used
    II.Transverse Variation of Local Properties when Coales-cence-Suppressing Media Are Used
    III.Transverse Variation of Local Properties as a Result of Inserting O2 Electrodes and/or Tilting the Column.
    European Journal Appl. Microbiol. Biotechnol. 7 (1979), Part I: 135-145; Part II: 241-249; Part III: 333-341.
     
  271. Buchholz, R.; Schügerl, K.:
    Methods for Measuring the Properties of the Turbulence in Bubble Flow.
    European Journal Appl. Microbiol. Biotechnol. 7 (1979), 11-20.
     
  272. Buchholz, R.; Schügerl, K.:
    Methods for Measuring the Bubble Size in Bubble Column Bioreactors.
    Part I + II European Journal Appl. Microbiol. Biotechnol. 6 (1979), Part I: 301-313, Part II: 315-323.
     
  273. Buchholz, R.; Schügerl, K.:
    Bubble column bioreactors.
    European Journal of Applied Microbiology and Biotechnoloy 6(4) (1979), 301-313.
     
  274. 1978
     
  275. Buchholz, H.; Buchholz, R.; Niebeschütz, H.; Schügerl, K.:
    Absorption of Oxygen in Highly Viscous Newtonian and Non-Newtonian Fermentation Model Media in Bubble Column Bioreactors.
    European Journal Appl. Microbiol. Biotechnol. 6 (1978), 115-126.
     
  276. Buchholz, H.; Buchholz, R.; Lücke, J.; Schügerl, K.:
    Bubble Swarm Behaviour and Gas Absorption in Non-Newtonian Fluids in Sparged Columns.
    Chem. Eng. Sci. 33 (1978), 1061-1070.
     
  277. Buchholz, H.; Buchholz, R.; Lücke, J.; Schügerl, K.:
    Begasung hochviskoser Kulturmedien in Blasensäulen-Bioreaktoren.
    Chem.-Ing.-Tech. 50 (1978), 227.
     
  278. Oels, U.; Lücke, J.; Buchholz, R.; Schügerl, K.:
    Influence of Gas Distributor Type and Composition of Liquid on the Behaviour of a Bubble Column Bioreactor.
    Ger. Chem. Eng. 1 (1978), 115-129.
     
  279. König, B.; Buchholz, R.; Lücke, J.; Schügerl, K.:
    Longitudinal Mixing of the Liquid Phase in Bubble Columns.
    Ger. Chem. Eng. 1 (1978), 199-205.
     
  280. Buchholz, H.; Buchholz, R.; Lücke, J.; Schügerl, K.:
    Gasification of highly viscous culture media in bubble column bioreactors.
    Chemie Ingenieur Technik 50(3)(1978), 277.
     
  281. Hallersleben, J.; Buchholz, R.; Lücke, J.; Schügerl, K.:
    Blasenbildung und -verhalten im dynamischen Bereich.
    Chemie Ingenieur Technik 50(1978), 143.
     
  282. 1977
     
  283. König, B.; Buchholz, R.; Lücke, J.; Schügerl, K.:
    Axiale Durchmischung der Flüssigkeit in Blasensäulen mit Flüssigkeitsgemischen.
    Chem.-Ing.-Tech. 49 (1977), 661.
     
  284. Buchholz, R.:
    Guide: Fundamental knowledge on water. Feed water treatment - waste water purification.
    Textil Praxis International, 32(7)(1977), 841-2.
     
  285. Buchholz, R.:
    Guide: Basic knowledge about water - mill's water preparation - waste cleaning.
    Textil Praxis International, 32(5)(1977), 565-6, 575.
     
  286. Buchholz, R.:
    Guide: Basic knowledge about water - mill's water preparation - waste cleaning.
    Textil Praxis International, 32(4)(1977), 458-61.
     
  287. Buchholz, R.:
    Guide: Basic water science. Feed water treatment - waste water purification.
    Textil Praxis International, 32(6)(1977), 720-1.
     
  288. Hallensleben, J.; Buchholz, R.; Lücke, J.; Schügerl, K.:
    Blasenbildung und -verhalten im dynamischen Bereich.
    Chem.-Ing.-Tech. 49 (1977), 663.

     
 
 
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